The abundance of deleterious polymorphisms in humans |
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| Authors: | Subramanian Sankar |
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| Affiliation: | Australian Rivers Institute, Griffith School of Environment, Griffith University, Nathan, Queensland 4111, Australia. s.subramanian@griffith.edu.au |
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| Abstract: | ![]()
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans. |
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