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Properties of Ionotropic Glutamate Receptors Revealed by Channel Blockade |
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| Authors: | Magazanik L. G. Tikhonov D. B. Bolshakov K. V. Gmiro V. E. |
| Affiliation: | (1) Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia;(2) Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint Petersburg, Russia |
| Abstract: | In experiments on hippocampal and striatal neurons, it was demonstrated using specific blockers with different three-dimensional structures that the main difference between channel binding sites in the AMPA and NMDA receptors is the dissimilar location of the nucleophilic region. |
| Keywords: | ionotropic glutamate receptors NMDA and AMPA receptor channels adamantane phenylcyclohexyl mono- and dicationic derivatives |
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