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A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods |
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| Authors: | Hernandez-Folgado Laura Schmuck Carsten Tomić Sanja Piantanida Ivo |
| Institution: | aLaboratory for Supramolecular and Nucleoside Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, HR 10002 Zagreb, POB 180, Croatia bLaboratory for Chemical and Biological Crystallography, Ruđer Bošković Institute, Zagreb, Croatia cInstitut für Organische Chemie, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany |
| Abstract: | At micromolar concentrations and equimolar conditions in respect to basepairs, a novel pyrene-guanidiniocarbonyl-pyrrole cation 1 exhibited a strong ICD signal at about λ = 300 nm specifically upon the interaction with ds-DNA, while under the same conditions a new fluorescence maximum at λ = 480 nm appeared exclusively upon the addition of ds-RNA. |
| Keywords: | Guanidinium Pyrene Pyrrole ds-DNA ds-RNA |
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