The effect of intra-uterine prostaglandin F2α on corpus luteum function in the human

Prostaglandin F_2α (PGF_2α) was administered via a Foley catheter over a 12 hour period to 8 healthy volunteers awaiting laparoscopic sterilisation. The amount of PGF_2α infused varied between 500 μg and 2000 μg every 2 hours for 6 doses. Plasma progestins and oestradiol 17β, and urinary estrogens and pregnanediol were assayed throughout the study period.There was no evidence of luteolysis in any patient although vaginal bleeding of varying duration occurred in all women within 36 hours of administration of PGF_2α.