血UA水平与急性脑梗死患者颈动脉斑块及梗死分型的关系

目的:探讨血尿酸(UA)水平与急性脑梗死(ACI)患者颈动脉斑块及梗死分型的关系。方法:选择2013年11月~2016年5月本院收治的ACI患者200例,依据牛津郡社区卒中研究分型(OCSP)标准将患者分为完全前循环梗死(TACI)组,部分前循环梗死(PACI)组、后循环梗死(POCI)组和腔隙性梗死(LACI)组;依据斑块性质将所有患者分为无斑块组、稳定斑块组和不稳定斑块组,分析不同梗死分型和斑块性质患者血UA水平差异。结果:TACI组与PACI组、POCI组与LACI组组间UA水平比较差异无统计学意义(P0.05),而TACI组和PACI组均高于POCI组和LACI组,差异有统计学意义(P0.05);UA水平与OCSP分型存在相关性(r=0.237,P=0.001);无斑块组UA水平与稳定斑块组的差异无统计学意义(P0.05);不稳定斑块组UA水平显著高于无斑块组和稳定斑块组,差异有统计学意义(P0.05),UA水平与不同斑块性质分型存在相关性(r=0.356,P=0.000);ACI患者总体OCSP分型和斑块性质存在相关性(r=0.334,P=0.000)。结论:血UA水平与ACI患者颈动脉斑块及梗死分型存在相关性,应重视ACI患者UA水平的检测,以预防脑梗死。

Relation of Blood Uric Acid Levels with Cerebral Infarction and Plaque Type of Acute Cerebral Infarction Patients

ABSTRACT Objective: To explore the relation of blood uric acid levels with cerebral infarction and plaque type of acute cerebral infarction (ACI) patients. Methods: 200 ACI patients admitted to our hospital from November 2012 to May 2016 were selected, All pa- tients were divided into total anterior circulation infarction group(TACI), partial anterior circulation infarction(PACI) group, posterior cir- culation infarction(POCI) group and lacunar infarction(LACI) group according to Oxfordshire community stroke project (OCSP) classifi- cation criteria;And all patients were divided into no plaque group, stable plague group and unstable plaque group according to plaque type, the relation of blood uric acid levels with cerebral infarction and plaque type were analyzed. Results: The difference of UA level be- tween TACI group and PACI group, POCI group and LACI group were both not statistically significant(P>0.05). The UA level of TACI group and PACI group were higher than those of POCI group and LACI group (P<0.05). UA levels and OCSP classification of ACI pa- tients was correlated (r=0.237, P=0.001). The difference of UA level between no plaque group and stable plaque group was not statistically significant (P>0.05).UA level of unstable plaque group was significantly higher than those in no plaque group and stable plague group, the difference was statistically significant (P<0.05). Plaque type and OCSP classification was correlated (r=0.356, P=0.000). OCSP classi- fication and plaque type were correlated (r=0.334, P=0.000). Conclusion: Blood UA levels and cerebral infarction and plaque type of ACI patients were correlated,attentions should be paid to UA levels of ACI patients to preventive cerebral infarction.