血府逐瘀丸治疗老年2型糖尿病伴失眠的临床疗效及其对认知功能的影响

目的:探究血府逐瘀丸治疗老年2型糖尿病伴失眠患者的临床疗效及其对认知功能影响。方法:选取43例我院收治的老年2型糖尿病伴失眠患者,将其随机分为实验组及对照组。对照组21例予地西泮治疗,实验组22予血府逐瘀丸治疗。观察两组治疗前后失眠症状及认知功能的变化情况。结果:治疗后,实验组总有效率(86.4%)高于对照组(61.9%),其差异经比较有统计学意义(P0.05);两组匹兹堡睡眠质量指数量表(PSQI)评分均较治疗前显著降低(P0.05),与对照组相比,实验组PSQI评分较低(P0.05),空腹血糖水平较低(P0.05),蒙特利尔认知评估量表(MoCA)评分较高(P0.05)。结论:血府逐瘀丸可有效降低老年2型糖尿病伴失眠患者的血糖水平,提升睡眠质量,改善失眠及认知功能障碍。

Clinical Efficacy of Xuefu Zhuyu Pill in the Treatment of Senile type 2 Diabetes Mellitus with Insomnia and Its Cognitive Function

ABSTRACT Objective: To investigate the clinical efficacy of xuefu zhuyu pill in the treatment of senile type 2 diabetes mellitus with insomnia and its cognitive function. Methods: 43 senile patients with type 2 diabetes mellitus and insomnia who were treated in our hospital were selected and randomly divided into the experiment group and control group. 21 cases in the control group were treated with diazepam treatment, 22 cases in the experiment group were treated with xuefu zhuyu pill treatment. After treatment for 28 days, the in- somnia and cognitive function changed situations of both groups were observed before and after treatment. Results: After treatment, the total effective rate of experiment group(86.4%) was higher than the control group(61.9%) (P<0.05); the Pittsburgh sleep quality index - scale (PSQI) scores of both groups were decreased (P<0.05), compared with the control group, the PSQI score, fasting blood glucose level of the experiment group were lower(P<0.05), the montreal cognitive assessment scale(MoCA) score was higher(P<0.05). Conclusion: Xuefu zhuyu pill could effectively decrease the blood glucose, improve the sleep quality, insomnia and cognitive dysfunction of senile type 2 diabetes mellitus patients with insomnia.