普拉洛芬滴眼液治疗2型糖尿病合并干眼症的临床疗效

目的:探讨普拉洛芬滴眼液治疗2型糖尿病合并干眼症的临床疗效。方法:选取我院收治的2型糖尿病合并干眼症患者70例,随机分为对照组和实验组,每组35例。对照组患者采用人工泪液滴眼治疗,实验组患者在对照组基础上采用普拉洛芬滴眼液治疗。观察并比较治疗前后两组患者泪膜破裂时间、基础泪液分泌量、角膜荧光染色阳性率及临床疗效。结果:实验组总有效率高于对照组(P0.05);与治疗前相比,两组患者泪膜破裂时间延长、基础泪液分泌量及泪液中的溶菌酶、EGF及LF水平明显升高(P0.05),角膜荧光染色阳性反应发生率降低(P0.05);治疗后与对照组相比,实验组患者泪膜破裂时间较长、基础泪液分泌量较高,溶菌酶、EGF及LF水平较高(P0.05),角膜荧光染色阳性反应发生率较低(P0.05)。结论:普拉洛芬滴眼液对2型糖尿病并发干眼症患者的治疗临床疗效良好,推测其机制与泪膜破裂时间的延长、基础泪液分泌量增加及溶菌酶、EGF及LF水平的升高有关。

Effect of Pranoprofen in Patients with Type 2 Diabetes and Xerophthalmia

ABSTRACT Objective: To investigate the effect of pranoprofen in patients with type 2 diabetes and xerophthalmia. Methods: 70 patients with Type 2 diabetes and xerophthalmia who were treated in our hospital were selected and randomly divided into the control group and the experiment group, with 35 cases in each group. The patients in the control group were treated with artificial tears eye drops, while the patients in the experiment group were treated with pranoprofen on the basis of the control group. Then the tear break-up time, schirmer, corneal fluorescein staining positive rate and clinical efficacy were observed and compared between two groups before and after treatment. Results: Compared with the control group, the clinical efficacy rate in the experiment group was higher (P<0.05). Compared with before treatment, the tear break-up time prolonged, basic tear secretion, tear lysozyme, and the levels of EGF and LF were higher in the two groups after treatment, while the positive reaction rate of corneal fluorescence staining were lower (P<0.05). Compared with the control group after treatment, the tear break-up time prolonged, basic tear secretion, tear lysozyme, and the levels of EGF and LF in the experiment group were higher, while the positive reaction rate of corneal fluorescence staining was lower (P<0.05). Conclusion: Pranoprofen eyedrops has better clinical efficacy on the treatment of type 2 diabetes mellitus and xerophthalmia. It is speculated that the mechanism and tear break-up time prolonged, basal tear secretion increase and lysozyme, epidermal growth factor (EGF) and LF increased.