动脉介入溶栓术治疗急性脑梗死的临床疗效

目的:探究动脉介入溶栓术对急性脑梗死患者的临床疗效。方法:选择我院收治的急性脑梗死患者43例并随机划分成实验组以及对照组。对照组19例予静脉内尿激酶溶栓,实验组24例予尿激酶动脉内溶栓。比较两组临床疗效、治疗前后血清脑钠肽及Hcy水平的变化。结果:实验组总有效率显著高于对照组,差异具有统计学意义(P0.05)。治疗后,两组患者血清脑钠肽、同型半胱氨酸(Hcy)水平及NIHSS评分均较治疗前降低,且与对照组比较,实验组血管总再通率较高、NIHSS评分、血清脑钠肽及Hcy水平较低,差异具备有统计学意义(P0.05)。结论:动脉介入溶栓术治疗急性脑梗死患者能够有效提高血管再通率、NIHSS评分及临床疗效,推测其与降低患者血清脑钠肽及Hcy水平相关联。

Effects of Arterial Interventional Thrombolysis on the Patients with Acute Cerebral Infarction

ABSTRACT Objective: To investigate the effects of arterial interventional thrombolysis on the patients with acute cerebral infarc- tion. Methods: 43 patients with acute cerebral infarction who were treated in our hospital were selected and randomly divided into the ex- perimentalal group and control group. 19 cases in the control group were treated by intravenous thrombolysis with urokinase, 24 cases in the experimental group were treated by intra arterial thrombolysis with urokinase. The clinical efficacy, serum brain natriuretic peptide and Hcy levels before and after treatment were compared between the two groups. Results: The total effective rate of experimental group was higher than that of the control group(P<0.05); the serum brain natriuretic peptide, homocysteine (Hcy) level and the NIHSS score of both groups were decreased after treatment; compared with the control group, the total vascular patency rate of experimental group was higher, the NIHSS score, serum brain natriuretic peptide and Hcy levels were lower (P<0.05). Conclusion: Arterial interventional throm- bolysis could effectively improve the vascular patency rate, NIHSS score and clinical efficacy in the treatment of patients with acute cere- bral infarction, which might be related to reduce the serum brain natriuretic peptide and Hcy levels.