连续负荷量新活素治疗难治性心力衰竭患者的临床疗效观察

目的:探讨连续负荷量新活素治疗难治性心力衰竭患者的临床疗效。方法:选取我院收治的65例难治性心力衰竭患者,随机分为两组。对照组在常规治疗的基础上加用硝酸甘油注射液,观察组在常规治疗的基础上加用新活素,比较两组的疗效,治疗前和治疗后24、36、48 h的肺动脉楔压(PAWP)、肺动脉压(PAP)、血清高敏C反应蛋白(hs-CRP),脑利钠肽(BNP)水平的变化。结果:治疗后,观察组有效率为87.9%,显著高于对照组(65.6%,P0.05)。两组患者治疗后24、36、48 h的PAWP和PAP降低值逐渐增加,且观察组PAWP和PAP降低值均显著高于对照组同时点(P0.05)。两组治疗后24、36、48 h血清hs-CRP、BNP水平随着时间延长而逐渐下降(P0.05),观察组治疗后24、36、48 h的血清hs-CRP、BNP水平均低于对照组同时点(P0.05)。结论:在基础治疗之上,给予连续负荷量新活素对于治疗难治性心力衰竭可提高治疗效果,减轻心脏前负荷,降低hs-CRP,BNP水平,改善心肌重构。

Effects of Continuous Loading Volume of New Living Factor on Patients with Refractory Heart Failure and Related Clinical Indicators

ABSTRACT Objective: To investigate the clinical effects of continuous load volume new living factor on the refractory heart failure. Methods: 65 cases of patients with refractory heart failure patients were randomly divided into two groups. The control group was given conventional treatment and Nitroglycerin Injection, and the observation group was given new living factor with conventional treatment. The curative effect, changes of pulmonary artery wedge pressure (PAWP), pulmonary artery pressure (PAP), serum anti hs-CRP, brain natriuretic peptide (BNP) levels before treatment and at 24, 36, 48 h after treatment were compared between the two groups. Results: After treatment, the effective rate of observation group was 87.9%, which was higher than that of the control group (65.6%, P<0.05). The re- duction value of PAWP and PAP levels of both groups were gradually increased at 24, 36, 48 h after treatment, which were significantly higher in the observation group than those of the control group at the same time points(P<0.05). At 24, 36, 48 h after treatment, the serum hs-CRP and BNP levels were decreased with the extension of treatment time(P<0.05), which were significantly lower in the observation group than those of the control group at the same time points(P<0.05). Conclusion: Based On the conventional treatment, continuous loading volume of new living factor can improve the therapeutic effect, and reduce cardiac preload, hs-CRP and BNP levels, improve the myocardial remodeling of patients with refractory heart failure.