腺苷和一氧化氮在中枢神经系统相互作用及与癫痫相关性

腺苷和一氧化氮(Nitric oxide,NO)都是十分活跃的具有多种生物活性的内源性物质。近年来,关于腺苷和NO在周围组织和中枢神经系统中的相互作用被广泛关注。腺苷在中枢神经系统中广泛存在,可作为整合中枢兴奋和抑制性神经递质的调节因子;NO在中枢神经系统中具有广泛的生物学意义,既兼有第二信使和神经递质的性能,又是效应分子,参与多种生理功能,代谢衍生物有一定的中枢神经毒性。在中枢神经系统中,腺苷和NO之间可能有一定联系,本文综述了二者在中枢神经系统中的相互作用及其与癫痫的相关性,以期为中枢神经系统相关疾病的发病机制研究及防治方法提供新的思路。

Interaction between Adenosine and Nitric Oxide in the Central Nervous System and Relationship with the Therapy of Epilepsy

ABSTRACT: Adenosine and nitric oxide (NO) are very active endogenous substances with a variety of biological activities. In re- cent years, the interaction between adenosine and NO in the peripheral tissues and central nervous system (CNS) has been extensively concerned. Adenosine in the CNS is widespread, which can be used as the integration of the central excitatory and inhibitory neurotrans- mitter regulator. NO has extensive biological significance in the CNS, act as a second messenger, neurotransmitter and an effector molecule which involved in a variety of physiological functions. The metabolic derivatives of NO have certain central nervous system toxicity. Emerging studies have shown that adenosine and NO may have some interactions in the CNS. Here, we reviewed the interac- tions between adenosine and NO in CNS and its relationship with the therapy of epilepsy, in order toprovide novel ideas for CNS-related diseases therapy.