孟鲁斯特纳联合玉屏风颗粒治疗小儿过敏性鼻炎的临床疗效

目的:探讨孟鲁斯特纳联合玉屏风颗粒治疗小儿过敏性鼻炎患者的临床疗效及安全性。方法:选取于我院进行治疗的小儿过敏性鼻炎患者60例,根据电脑生成的随机数字表将所有患者随机分为实验组与对照组,每组各30例。对照组患者给予孟鲁斯特纳进行治疗,实验组患者在对照组的基础上联合使用中药制剂玉屏风颗粒进行治疗。比较两组患者治疗前后血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白E(IgE)、白介素6(IL-6)、白介素17(IL-17)及白介素23(IL-23)水平,并对两组患者治疗过程中的不良反应进行记录,评价两组患者的临床疗效。结果:与治疗前相比,两组患者治疗后的血清IgA、IgG水平均升高(P0.05),IgE、IL-6、IL-17及IL-23水平均降低(P0.05);与对照组相比,实验组患者血清IgA、IgG水平及临床总有效率较高(P0.05),IgE、IL-6、IL-17、IL-23水平及不良反应发生率较低(P0.05)。结论:孟鲁斯特纳联合玉屏风颗粒治疗小儿过敏性鼻炎安全有效,可能与其影响机体血清IgA、IgG、IgE、IL-6、IL-17及IL-23水平有关。

Clinical Effect of Montelukast Sodium Union Yuping Wind Particles on the Allergic Rhinitis in Children

ABSTRACT Objective: To investigate the effect of montelukast sodium and Yupingfeng particles on the total serum immunoglobu- lin levels and clinical efficacy in the treatment of allergic rhinitis in children. Methods: 60 children with allergic rhinitis from our hospital were selected and randomly divided into the the control group and the experiment group with 30 cases in each group. The control group were treated with montelukast sodium and the experiment group were treated with Yupingfeng particles on the basis of the control group. Then the levels of serum immune globulin protein A (IGA), immunoglobulin protein G (IgG), immunoglobulin protein E (IGE), interleukin 6 (IL-6), interleukin 17 (IL) and interleukin 23 (IL-23) between two groups were observed and compared before and after the treatment, and the adverse reactions of the two groups were recorded, and the clinical effect were evaluated. Results: Compared with be- fore treatment, the serum levels of IgA and IgG were higher, and the levels of IgE, IL-6, IL-17 and IL-23 were lower in the two groups af- ter the treatment (P<0.05); Compared with the control group, the serum levels of IgA and IgG were higher, and the levels of IgE, IL-6, IL-17 and IL-23 levels were lower in the experiment group after the treatment (P<0.05). Compared with the control group, the incidence of adverse reactions in the experiment group was lower, and the clinical total effective rate was higher (P<0.05). Conclusion: Montelukast sodium combined with Yupingfeng granules in the treatment of children with allergic rhinitis is safe and effective, which is worthy of clinical application.