射波刀立体定向放疗技术治疗结直肠癌肝转移癌的疗效观察

目的:探讨射波刀立体定向放疗技术治疗结直肠癌肝转移癌的疗效观察。方法:选择2014年1月至2016年2月我院收治的64例结直肠癌肝转移癌患者为研究对象,按照随机数字表法随机分为对照组(32例)和治疗组(32例),对照组患者给予FOLFOX6全身化疗方案,治疗组患者给予FOLFOX6全身化疗和肝脏病灶立体定向放疗(射波刀)治疗。观察患者的治疗3个月后的近期临床疗效和不良反应,6个月后患者生存率和局部控制率,并评价患者的生活质量。结果:治疗3个月后,治疗组患者的总有效率为78.13%,高于对照组的53.13%,差异有统计学意义(P0.05);治疗6个月后,治疗组的生存率(96.88%)和局部控制率(87.50%)均高于对照组(81.25%和65.63%),差异有统计学意义(P0.05);治疗6个月后,治疗组患者的情绪功能、认知功能、角色功能、躯体功能、社会功能评分均高于对照组,差异有统计学意义(P0.05)。两组患者的不良反应发生率比较差异无统计学意义(P0.05)。结论:射波刀立体定向放疗技术治疗结直肠癌肝转移癌具有较好的近期临床疗效,可提高患者的生存率和局部控制率,改善患者生活质量,且不良反应发生率低,值得临床推广应用。

Clinical Efficacy of Cyberknife Stereotactic Body Radiotherapy Technology on Treatment of Colorectal Cancer Liver Metastatic Carcinoma

ABSTRACT Objective: To study the clinical efficacy of cyberknife stereotactic body radiotherapy technology on treatment of colorectal cancer liver metastatic carcinoma. Methods: 64 patients with colorectal cancer liver metastatic carcinoma were divided into control group (32 cases) and treatment group (32 cases), according to random number table method, in our hospital from January 2014 to February 2016. The control group was given FOLFOX6 systemic chemotherapy regimens, and the treatment group was given cyberknife stereotactic body radiotherapy combined with FOLFOX6 systemic chemotherapy. After 3 months the recent clinical curative effect and adverse reaction were observed. After 6 months the survival rate, local control and patient''s quality of life were evaluated. Results: After 3 months treatment, the total effective rate 78.13% in treatment group was higher than that of the control group 53.11%, the difference was statistically significant (P<0.05). After 6 months of treatment, the survival rate (96.88%) and local control rate (87.50%) of the treatment group were significantly higher than those in the control group (65.63% and 81.25%), and the difference was statistically significant (P<0.05); After 6 months of treatment, the emotional function, cognitive function, role function, physical function and social function score of the treatment group were higher than those of the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Radio wave knife stereotactic radiotherapy technology for the treatment of colorectal liver metastases cancer has better clinical effect in the near future, can improve the survival rate and local control rate,improve the quality of life of patients, and the incidence of adverse reactions was low, it is worthy of clinical application.