中性粒细胞NADPH氧化酶与组织缺血再灌注关系的研究进展

缺血再灌注损伤为心肌梗死,器官移植,肠道灌注不足,脑中风等疾病或手术的常见并发症,是导致危重病人死亡的重要因素,然而至今临床上仍未有十分理想的治疗方法。在组织缺血再灌注过程中,中性粒细胞通过NADPH(Nicotinamide-adenine dinucleotide phosphate)氧化酶的活化产生大量活性氧(Reactive oxygen species,ROS),一方面参与氧化应激,另一方面进一步招募中性粒细胞,扩大炎症反应,造成组织损伤。本文综述了国外期刊报道的中性粒细胞NADPH氧化酶与组织缺血再灌注损伤的相关研究进展,以期为心脑血管等重大疾病防治提供一定线索。

Advances in Study on Relationship between Neutrophil NADPH Oxidase and Tissue Ischemia Reperfusion

ABSTRACT: Ischemia reperfusion injury is a common complication of diseases or surgeries such as myocardial infarction, organ transplantation and stroke. It is a leading cause of death of critical patients while satisfying treatments still remains to be developed. During ischemia and reperfusion, neutrophils release a large amount of reactive oxygen species (ROS) to contribute to oxidative stress and recruit more neutrophils to ischemic tissue which expands the inflammatory response and results in tissue injury. Research progresses published in foreign journals on the connection between neutrophil Nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase and tissue ischemia reperfusion injury have been reviewed in this review, so as to provide evidences for the prevention and treatment of major diseases such as cardiovascular and cerebrovascular diseases.