Nucleobindin-2 在乳腺癌中表达的临床病理意义

目的:探讨NUCB2在乳腺癌中的表达及临床病理意义。方法:收集乳腺癌病例及相应的临床资料包括随访资料应用免疫组织化学技术检测良性病变,有/无淋巴结转移的乳腺癌及配对淋巴结转移灶中NUCB2的表达,分析NUCB2表达与乳腺癌临床病理指标和生存状态间的关系。结果:免疫组化结果:显示NUCB2在BBD、MBC、NMBC、PMLN的阳性表达率分别为90.0%(45/50),82.1%(87/106)、48.2%(40/83)、47.2%(50/106)。其中,NUCB2在BBD的阳性表达率显著高于NMBC、PMLN,而与MBC无显著性差异;在MBC中的阳性表达率显著高于NMBC;在MBC中的阳性表达率显著高于PMLN。临床病理分析结果:显示乳腺癌原发灶中NUCB2表达与淋巴结转移(p=0.000)、临床分期(p=0.001)、雌激素阳性表达(p=0.020)具有显著性相关。而与年龄、肿块大小、组织学分级、组织学类型、孕激素受体、HER2表达、绝经情况无显著相关。Kaplan-Meier分析结果:显示NUCB2阳性表达病例的总生存率比阴性病例更短(P=0.004)。结论:NUCB2在乳腺癌中表达与淋巴结转移、临床分期、雌激素受体表达和生存状态相关,可能在乳腺癌恶性演进和预后中具有重要意义。

Clinicopathological Significance of Nucleobindin-2 Expression in Breast Cancer

Objective:To investigate the expression and clinical significance of NUCB2 in breast cancer, and provide evidence for its functional research.Methods:Cases of breast cancer and the corresponding clinical data including follow-up data were collected, immunohistochemical method was used to detect the benign lesions, with/without lymph node metastasis of breast cancer and matched lymph node metastasis foci of nucb2 expression. The relationship between nucb2 expression in breast cancer and clinicopathological parameters, survival state were analyzed.Results:Immunohistochemical results showed that the positive expression rates of NUCB2 in BBD, MBC, NMBC and PMLN were 90% (45/50), 82.1% (87/106), 48.2% (40/83), 47.2% (50/106) respectively. The positive expression rate of NUCB2 in BBD was significantly higher than that of PMLN and NMBC, but there was no significant difference in MBC. The positive expression rate of MBC in was significantly higher than that in NMBC; the positive expression rate NUCB2 in MBC was significantly higher than that in PMLN. Clinical pathological analysis showed that the expression of NUCB2 was significantly associated with lymph node metastasis (p=0.000), clinical stage (p=0.001) and estrogen positive expression (p=0.020) in primary breast cancer. But there was no significant correlation with age, tumor size, histological grade, histological type, progesterone receptor, HER2 expression, and menopause. Kaplan-Meier analysis, the results showed that the overall survival rate of NUCB2 positive expression cases was lower than that of the negative cases (p=0.004).Conclusion:NUCB2 expression in breast cancer was closely related to the lymph node metastasis, clinical stage,. estrogen positive expression, survival status, which might be important significance in malignant progression and prognosis.