颅内动脉瘤和动静脉畸形患者VEGF的表达及与临床特征的关系

目的:探究颅内动脉瘤和动静脉畸形(AVM)患者血管内皮生长因子(VEGF)的表达与临床特征的关系。方法:选取2011年2月至2015年11月期间因颅内动脉瘤和AVM入院接受治疗的64例患者作为研究对象,AVM和动静脉畸形患者各32例。将样本切片进行VEGF免疫组化染色,记录染色位置、染色强度,计算阳性指数。分析颅内动脉瘤患者在不同年龄段和HuntHess分级中VEGF表达水平差异,分析AVM患者在不同直径、年龄段、Spetzler分级中VEGF表达的情况。结果:不同年龄段颅内动脉瘤患者VEGF表达差异无统计学意义(P0.05),不同HuntHess分级颅内动脉瘤患者VEGF表达差异显著(P0.05)。AVM中动脉VEGF的阳性率显著低于静脉中的阳性率,差异有统计学意义(P0.05)。AVM患者在不同Spetzler分级、不同直径及不同年龄段中VEGF表达差异无统计学意义(P0.05)。结论:VEGF表达在AVM患者的静脉和动脉中存在差异,与颅内动脉瘤年龄及AVM大小、年龄无相关性,VEGF不能作为颅内动脉瘤和AVM患者临床预后的预测指标。

Intracranial Aneurysm and Arteriovenous Malformation: Relationship of Expression of VEGF and Clinical Features

ABSTRACT Objective: To investigate the relationship of expression of vascular endothelial growth factor(VEGF) and clinical fea- tures in patients with intracranial aneurysm and arteriovenous malformation(AVM). Methods: A total of 64 patients with AVM and in- tracranial aneurysm, who were treated in First Hospital of Shijiazhuang from February 2011 to November 2015, were chosen as research subjects, AVM were 32 cases and intracranial aneurysm were 32 cases. The samples were sectioned for VEGF immunohistochemical staining; the location and intensity of staining were recorded; the positive indexes were computed. The VEGF expression of different age and Hunt&Hess classification in patients with intracranial aneurysms were analysed;the VEGF expression of different diameters, ages, Spetzler classification in patients with AVM were analysed. Results: There were no statistical differences in the VEGF expression of dif- ferent ages in patients with intracranial aneurysms (P>0.05); the VEGF expression of different Hunt&Hess classification in patients with intracranial aneurysms was statistical difference(P<0.05). The positive rate of VEGF in the artery of AVM was lower than that in the vein, the difference was statistically significant(P<0.05). There were no statistical differences in the VEGF expression of the different Spetzler classification, different diameters and different ages in patients with AVM (P>0.05). Conclusion: The expression of VEGF in the vein and the artery of patients with AVM is different,the expression of VEGF is not correlated with the age of intracranial aneurysm and the size and age of AVM.VEGF cannot be used as a predictor in the patients with intracranial aneurysms and AVM.