Sestrins参与调解代谢稳态相关机制的研究进展

Sestrins是一类进化上保守的蛋白质家族,它们作为代谢稳态的重要调节剂,抑制氧化应激,参与一磷酸腺苷激活的蛋白激酶(AMPK)-哺乳动物雷帕霉素靶点(m TOR)信号通路等重要活动。在脊椎动物中,Sestrin基因失活导致氧化损伤,脂肪堆积,线粒体功能障碍,肌肉变性等加速组织衰老的多种代谢病理状态。近年来,Sestrins调节代谢和对抗衰老的功能及机制已被越来越多的研究结果发现和证实。然而其确切作用机制尚不明确。因此,对Sestrins功能和调节机制的深入研究将会给与代谢、衰老相关的疾病,例如糖尿病、癌症提供新的治疗理念。

Research Advances of MetabolismHomeostasis Regulated by Sestrins

As a family of evolutionarily conserved proteins, Sestrins suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK) -mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. In vertebrates, inactivation of Sestrin genes resulted in diverse metabolic pathologies, such as oxidative damage, fat accumulation, mitochondrial dysfunction, and muscle degeneration, that accelerated tissue aging. Recent years, the function and mechanism of metabolic regulation and anti-aging of Sestrins have been discovered and confirmed. Nevertheless, the exact mechanism still awaits more studies to be conducted. Thus, further investigation of Sestrin function and regulation should provide new insights into age-associated metabolic diseases, including diabetes and cancer.