卵巢囊性颗粒细胞瘤的临床病理学特征、诊断及鉴别诊断

目的:探讨卵巢囊性颗粒细胞瘤的临床病理学特征、诊断和鉴别诊断要点。方法:复习1例卵巢囊性颗粒细胞瘤患者的临床资料、肿物的大体以及镜下病理组织学特征、免疫组化染色特征。结果:患者左侧单房囊性颗粒细胞瘤,大小为14.6 cm×18.9 cm×9.8 cm,囊壁厚薄不均一;镜下可见内壁由颗粒细胞组成,细胞层数不一,可见典型的Call-Exner小体;免疫组化染色可见α-inhibin,Vimentin,CD99均阳性。结论:卵巢囊性颗粒细胞瘤可依据镜下发现不典型增生的颗粒细胞、典型的Call-Exner小体和核沟等特征性的组织形态学作出诊断。

Clinicopathologic Features, Diagnosis and Differential Diagnosis of Ovarian Cystic Granulosa Cell Tumor

ABSTRACT Objective: To explore the clinicopathologic features, diagnosis and differential diagnosis of ovarian cystic granulosa cell tumor. Methods: The clinical data of one case of ovarian cystic granulosa cell tumor were reviewed. And the gross and histological features of the tumor were studied. Results: The patient had a left-sided unilocular cystic granulosa cell tumor, with the size of 14.6 cm× 18.9 cm×9.8 cm and uneven thickness of capsule wall. Under the microscope, the wall was consisted of granule cell, and the cell layer was visible. The typical Call-Exner bodies were also found under the microscope. Immunohistochemical staining results indicated that the alpha - inhibin, vimentin and CD99 were positive. Conclusion: The cystic granule cell tumor of the ovary could be diagnosed on the base of the histological characteristics like microscopic finding of atypical proliferation of granulosa cells, typical Call-Exner bodies and nuclear grooves.