| 丝氨酸/精氨酸富集蛋白与肿瘤发生 |
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| 引用本文： | 付育,王英泽.丝氨酸/精氨酸富集蛋白与肿瘤发生[J].中国生物化学与分子生物学报,2017,33(6):527-532. |
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| 作者姓名： | 付育 王英泽 |
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| 作者单位： | 河北科技大学生物科学与工程学院，石家庄050018 |
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| 基金项目： | 国家自然科学基金项目（No. 81402305）；河北省自然科学基金项目（No. H2015208141）；河北省高等学校科学技术研究项目（No. BJ2016024）和河北科技大学校基金项目（No.SW28） |
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| 摘 要： | 富含丝氨酸和精氨酸的SR蛋白（serine/arginine-rich protein）是重要的剪接因子家族，广泛参与RNA加工过程，包括剪接、出核、稳定性及翻译。近年来的研究发现，SR蛋白家族成员大多在肿瘤组织中存在异常表达，有些SR蛋白甚至能够作为原癌基因，通过调控肿瘤相关基因的选择性剪接而参与细胞转化和肿瘤发生。本文综述了SR蛋白的不同成员在肿瘤发生中的作用及其调控肿瘤相关基因的机制，以期为相关肿瘤的研究与诊治提供新思路和新靶点。
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| 关 键 词： | 丝氨酸/精氨酸富集蛋白 剪接 肿瘤发生 |
| 收稿时间： | 2017-02-20 |
SR Proteins and Tumorigenesis |
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| FU Yu,WANG Ying-Ze.SR Proteins and Tumorigenesis[J].Chinese Journal of Biochemistry and Molecular Biology,2017,33(6):527-532. |
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| Authors: | FU Yu WANG Ying-Ze |
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| Institution: | College of Bioscience and Bioengineering, Hebei University of Science and Technology, Shijiazhuang 050018, China |
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| Abstract: | SR proteins (serine/arginine-rich protein), a family of important splicing factors, play multiple roles in RNA processing, including splicing, mRNA nuclear export, mRNA stability and translation. Recent studies revealed that the abnormal expressions of most SR proteins were deregulated in various tumor types. Importantly, several SR proteins, acting as proto-oncogenes, were found to contribute to cell transformation and tumor induction through regulating the alternative splicing of some tumor-related genes. In this review, we would highlight new findings on the role of SR proteins and its regulation in tumorigenesis, providing new ideas and new targets for tumor diagnosis and treatment. |
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| Keywords: | serine and arginine-rich proteins (SR) splicing tumorigenesis |
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