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Correlations between aminergic metabolites simultaneously obtained from human CSF and brain |
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| Authors: | M Stanley L Traskman-Bendz K Dorovini-Zis |
| Institution: | 1. Departments of Psychiatry Wayne State University School of Medicine, USA;2. Departments of Pharmacology Wayne State University School of Medicine, USA;3. Division Pharmacology, Lafayette Clinic, Detroit, MI 48207, USA;4. Department of Pathology, University of Michigan School of Medicine Ann Arbor, MI 48109, USA |
| Abstract: | Brain and cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were simultaneously measured in 48 individuals at autopsy. Concentrations of 5-HIAA and HVA in the cerebral cortex were positively correlated with their levels in the CSF for the same individual. Additionally a positive correlation was observed between postmortem CSF levels of 5-HIAA and HVA and a significant concentration gradient for both metabolites was observed in serial fractions of CSF. These findings suggest that determinations of 5-HIAA and HVA in CSF from living individuals may reflect brain metabolite levels as well as the functional activity of these specific neuronal systems. |
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