Polymorphism and divergence at the prune locus in Drosophila melanogaster and D. simulans |
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Authors: | Simmons GM; Kwok W; Matulonis P; Venkatesh T |
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Institution: | Department of Biology, City College, City University of New York, New York 10031. |
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Abstract: | The prune locus of Drosophila melanogaster lies at the tip of the X
chromosome, in a region of reduced recombination in which nearby loci show
reduced variation relative to evolutionary divergence from D. simulans. DNA
sequencing of prune alleles from D. melanogaster and D. simulans reveals
extremely low variation in D. melanogaster but greater variation in D.
simulans. Divergence between the two species is not reduced. This pattern
may be explained by either positive selection leading to hitchhiking of
neutral variation or background selection against deleterious mutations.
The pattern of silent versus replacement polymorphism and divergence at
prune is consistent with either a model of weakly deleterious selection
against amino acid substitutions or balancing selection.
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