| 代谢组学及其在环境毒理学中的应用 |
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| 作者姓名： | 林嘉意 谢炬 朱越平 谢文玉 |
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| 作者单位： | 广东石油化工学院，广东省石油化工污染过程与控制重点实验室，广东高校石油化工污染控制重点实验室，广东 茂名 525000 |
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| 基金项目： | 茂名市科技计划项目(2020KJZX031) |
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| 摘 要： | 代谢组学作为系统生物学的一部分，因其具有分析速度快的特点，被广泛用于生物医学等方面的研究。目前代谢组学在环境毒理学方面的研究主要针对单一污染物，但也需要考虑到被污染地的复杂情况。通过介绍代谢组学及其发展历程，总结了目前主流代谢组学技术的各自特点，讨论了代谢组学在环境重金属、有机污染物和抗生素中的毒性评估以及环境胁迫耐受性中的评价等方面内容，综述了其在环境毒理学中的应用，并指出其应用不足，旨在为代谢组学应用于环境毒理学的研究提供参考。
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| 关 键 词： | 代谢组学 环境毒理学 重金属 有机污染物 抗生素 |
| 收稿时间： | 2022-04-14 |
Metabolomics and its Application in Environmental Toxicology |
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| Authors: | Jiayi LIN Ju XIE Yueping ZHU Wenyu XIE |
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| Institution: | Guangdong Provincial Key Laboratory of Petrochemical Pollution Process and Control，Key Laboratory of Petrochemical Pollution Control of Guangdong Higher Education Institutes，Guangdong University of Petrochemical Technology，Guangdong Maoming 525000，China |
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| Abstract: | As a part of system biology， metabolomics is widely used in biomedical research because of its fast analysis. At present， the studies of metabolomics in environmental toxicology mainly focus on single pollutants， and the complex situation of contaminated areas should also be considered. The application of metabolomics in environmental toxicology was reviewed by introducing metabolomics and its development process. We also summarized the respective characteristics of the current mainstream metabolomics technology， and discussed the research and application progress of metabolomics in the toxicity evaluation of environmental heavy metals， organic pollutants and antibiotics， and environmental stress tolerance evaluation. At last， we pointed point out that the application of metabolomics in environmental toxicology needs to be strengthened. The paper was expected to provide reference for the application reasearch of metabonomics in environmental toxicology |
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| Keywords: | metabonomics environmental toxicology heavy metals organic pollutants antibiotics |
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