Beta-adrenergic receptor-linked adenylate cyclase in rat posterior pituitary |
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Authors: | E Stefanini A M Marchisio F Vernaleone P Devoto R Collu |
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Institution: | Institute of Pharmacology and Pharmacognosy University of Cagliari, Cagliari, Italy |
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Abstract: | A specific β-adrenergic-stimulated cyclic AMP generating system has been evidenced in rat posterior pituitary. This is clearly demonstrated by: 1) the adenylate cyclase (AC) affinity for stimulants was in the order ISO > NA > DA, and 2) propranolol, a specific β-adrenergic receptor blocker, was the only antagonist of the system. Clonidine and apomorphine were completely inactive, thus excluding an α-adrenergic and/or dopaminergic component in this AC system. Our data also indicate that dopaminergic receptors present in both pituitary lobes are not coupled to an AC. |
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