Bioassay‐Guided Isolation of Antifungal Compounds from Disporopsis aspersa (Hua) Engl. ex Diels against Pseudoperonospora cubensis and Phytophthora infestans |
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| Authors: | Feng Zhu Chengshan Yuan Fangli Gang Chaofu Yang Wenjun Wu Jiwen Zhang |
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| Institution: | 1. College of Chemistry & Pharmacy, Northwest A&F University, Yangling, P. R. China;2. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China;3. Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling, P. R. China |
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| Abstract: | Oomycetes are one type of the most highly destructive of the diseases that cause damage to some important crop plants, such as potato late blight, cucumber downy mildew, and grape downy mildew. As main approach of the ongoing search for new botanical fungicide from plant, the secondary metabolites of D. aspersa were investigated. Through efficient bioassay‐guided isolation, two new ( 1 and 2 ) and 12 known compounds ( 3 – 14 ) were isolated, and their structures were determined via extensive NMR, HR‐ESI‐MS, and IR. They were isolated from this genus for the first time except for compounds 11 and 12 . The biological properties of 1 – 14 were evaluated against Pseudoperonospora cubensis and Phytophthora infestans. Compounds 1 – 8 showed potent antifungal activity in vitro. Additionally, compound 3 has preferable control effect on cucumber downy mildew, showing dual effect of protection and treatment in vivo. |
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| Keywords: |
Disporopsis aspersa
isolation fungicidal activity
Pseudoperonospora cubensis
Phytophthora infestans
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