Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity

Authors:	Long Yun Oliver Higuchi Robert I Caferro Thomas R Lau Thomas L S Wu Min Cummings Marquis L Martinborough Esther A Marschke Keith B Chang William Y López Francisco J Karanewsky Donald S Zhi Lin

Affiliation:	^aDiscovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA

Abstract:	Modification on a lead series of [1,4]oxazino[3,2-g]quinolin-7-ones at the 2-position led to selective androgen receptor modulators with improved in vivo activity. The most potent analog (−)-33a exhibited full maintenance of levator ani muscle at 3 mg/kg and reduced activity on ventral prostate weight in a 2-week orally-dosed and orchidectomized rat maintenance assay.

Keywords:	Androgen SARM Testosterone Anabolic Androgenic Benzoxazine AR Muscle Oxazino[3,2-g]quinolin-7-one
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