| 瑞舒伐他汀对兔心肌梗死后心室重构及细胞凋亡的影响 |
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| 引用本文： | 钱炜春,张丰富,秦夏,丁竞竞,贾海波.瑞舒伐他汀对兔心肌梗死后心室重构及细胞凋亡的影响[J].现代生物医学进展,2011,11(15):2844-2847. |
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| 作者姓名： | 钱炜春 张丰富 秦夏 丁竞竞 贾海波 |
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| 作者单位： | 1. 南京医科大学附属南京市第一医院心内科,江苏南京,210000
2. 南京医科大学公共卫生学院,江苏南京,210000 |
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| 摘 要： | 目的:观察瑞舒伐他汀对新西兰大白兔心肌梗死后左室重构及心肌细胞凋亡的影响。方法:45只雄性新西兰大白兔随机分成三组,即:假手术组(S,n=15),心肌梗死对照组(MI,n=15),心肌梗死瑞舒伐他汀干预组(R,n=15)MI组和R组大鼠结扎左冠状动脉前降支建立AMI模型。心肌梗死对照组及假手术组术后24h灌等量的生理盐水。瑞舒伐他汀干预组于术后24h直接灌胃法给药,给药剂量以10mg/kg*d计算。干预2周后,进行心脏超声测定,随即处死新西兰大白兔、取出心脏,观察病理组织形态,并通过Western blot方法检测Bcl-2,Bax在心肌梗死边缘区的蛋白表达。结果:①心脏超声检测表明干预组左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)较心肌梗死对照组降低而左室射血分数(LVEF)较心肌梗死对照组增高②干预组心肌梗死边缘区Bax表达与心肌梗死对照组比较未见统计学差异,而Bcl-2表达高于心肌梗死对照组。结论:瑞舒伐他汀上调Bcl-2的表达,改善心室重构
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| 关 键 词： | 瑞舒伐他汀 心肌梗死 心室重构 基因 Bcl 基因 Bax |
Effects of Rosuvastatin on Ventricular Remodeling and Cardiomyocyte Apoptosis after Acute Myocardial Infarction in Albino Rabbit Model |
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| QIAN Wei-chu,ZHANG Feng-fu,QIN Xia,DING Jng-jing,JIA Hai-bo.Effects of Rosuvastatin on Ventricular Remodeling and Cardiomyocyte Apoptosis after Acute Myocardial Infarction in Albino Rabbit Model[J].Progress in Modern Biomedicine,2011,11(15):2844-2847. |
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| Authors: | QIAN Wei-chu ZHANG Feng-fu QIN Xia DING Jng-jing JIA Hai-bo |
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| Institution: | 1 (1 Nanjing First Hospital of Nanjing Medical University,210000,Nanjing,Jiangsu,China; 2 Public health college of Nanjing Medical University 210000,Nanjing,Jiangsu,China) |
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| Abstract: | Objective:To investigate the effects of rosuvastatin on ventricular remodeling and cardiomyo- cyte apoptosis after myocardial infarction.Methods:A total of 45 male New Zealand albino rabbits were randomly divided into three groups:sham operation group(S,n=15),AMI control group(MI,n=15) and AMI rosuvastatin intervention group(R,n=15).AMI models were made with the ligation of left anterior descending coronary artery in MI and R group.Rabbits in R group were administered rosuvastatin via direct gastric gavage ... |
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| Keywords: | Rosuvastatin Myocardial infarction Ventricular remodeling Apoptosis Genes Bcl-2 Bax |
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