Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis |
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| Authors: | Tri Komala Sari Suzanne M Pritchard Cristina W Cunha George A Wudiri Elizabeth I Laws Hector C Aguilar Naomi S Taus Anthony V Nicola |
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| Institution: | Department of Veterinary Microbiology and Pathology, Washington State Universitya;Animal Disease Research Unit, USDA-Agricultural Research Serviceb;Paul G. Allen School for Global Animal Health, Washington State University,c Pullman, Washington, USA |
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| Abstract: | Herpes simplex virus (HSV) proteins specifically required for endocytic entry but not direct penetration have not been identified. HSVs deleted of gE, gG, gI, gJ, gM, UL45, or Us9 entered cells via either pH-dependent or pH-independent endocytosis and were inactivated by mildly acidic pH. Thus, the required HSV glycoproteins, gB, gD, and gH-gL, may be sufficient for entry regardless of entry route taken. This may be distinct from entry mechanisms employed by other human herpesviruses. |
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