Inflammasomes in T cells |
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| Institution: | 1. Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany;2. Department of Medicine II, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany;1. Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA;3. Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;1. Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA;2. Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA;3. Tri-Institutional PhD Program, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, New York, USA;4. Tri-Institutional MD–PhD Program, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, New York, USA;1. Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA;2. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA;3. Department of Biomedical Engineering, University of Massachusetts, Amherst, MA, USA;4. Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA 01003, USA |
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| Abstract: | The concept of non-self recognition through germ-line encoded pattern recognition receptors (PRRs) has been well-established for professional innate immune cells. However, there is growing evidence that also T cells employ PRRs and associated effector functions in response to certain non-self or damage signals. Inflammasomes constitute a special subgroup of PRRs that is hardwired to a signaling cascade that culminates in the activation of caspase-1. Active caspase-1 processes pro-inflammatory cytokines of the IL-1 family and also triggers a lytic programmed cell death pathway known as pyroptosis. An increasing body of literature suggests that inflammasomes are also functional in T cells. On the one hand, conventional inflammasome signaling cascades have been described that operate similarly to pathways characterized in innate immune cells. On the other hand, unconventional functions have been suggested, in which certain inflammasome components play a role in unrelated processes, such as cell fate decisions and functions of T helper cells. In this review, we discuss our current knowledge on inflammasome functions in T cells and the biological implications of these findings for health and disease. |
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| Keywords: | inflammasome T cells T helper cells NLRP1 CARD8 pyroptosis |
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