1. Department of Biology and BioX Program, Stanford University, Stanford, CA 94305-5430, USA;2. Department of Human Genetics and Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA;3. Department for Structural Biology & Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN 38105-3678, USA
Abstract:
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Highlights? Yeast Hsp70 SSB binds cotranslationally to a defined set of nascent polypeptides ? SSB shows specificity for substrates highly challenged in cotranslational folding ? The heterodimeric cochaperone RAC modulates cotranslational SSB specificity ? Loss of SSB function leads to widespread misfolding and aggregation
