Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors |
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| Authors: | Alagille David Pfeiffer Bruno Scalbert Elizabeth Ferry Gilles Boutin Jean A Renard Pierre Viaud-Massuard Marie-Claude |
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| Affiliation: | EA 3247 Laboratoire de Chimie Organique, UFR des Sciences Pharmaceutiques, Université de Tours, 31 Avenue Monge, 37200 Tours, France. |
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| Abstract: | ![]()
The synthesis of new potential inhibitors of human chymase is described. Treatment of dihydroimidazo[1,5-a]indole and [1,5-b]isoquinoline-dione with thioaryl followed by oxidation gave the N-arylsulfonylmethyl of polycyclic hydantoin derivatives 3, 5 and 6. |
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