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Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides |
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| Authors: | Hashimoto Kentaro Tatsuta Miyuki Kataoka Mikayo Yasoshima Kayo Shogase Yuka Shimazaki Makoto Yura Takeshi Li Yingfu Yamamoto Noriyuki Gupta Jang B Urbahns Klaus |
| Institution: | Department of Chemistry, Research Center Kyoto, Bayer Yakuhin, Ltd, Kizu, Soraku, Kyoto 619-0216, Japan. kentaro.hashimoto@bayerhealthcare.com |
| Abstract: | A new class of benzimidazole-5-sulfonamides has been identified as nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Initial structure-activity relationships are presented resulting in compounds 19 and 28 with submicromolar dual functional activity on human and rat receptors. |
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