Synergism between A23187 and 1-oleoyl-2-acetyl-glycerol in superoxide production by human neutrophils |
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| Authors: | A Penfield M M Dale |
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| Affiliation: | Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, England |
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| Abstract: | Concentrations of the calcium ionophore A23187 and 1-oleoyl-2-acetyl-glycerol, which on their own are minimally effective in stimulating superoxide release from human neutrophils, show marked mutual potentiation when given simultaneously. The potentiating effect of the diacylglycerol can be shown to be dose-related. These results support the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil. |
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