| 多基因遗传病基因研究的策略和方法 |
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| 引用本文： | Zhang KX,Zhu DL,Huang W. 多基因遗传病基因研究的策略和方法[J]. 生理科学进展, 2001, 32(3): 215-219 |
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| 作者姓名： | Zhang KX Zhu DL Huang W |
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| 作者单位： | 上海第二医科大学附属瑞金医院上海市高血压研究所;国家人类基因组南方研究中心,;上海第二医科大学附属瑞金医院上海市高血压研究所,;国家人类基因组南方研究中心, |
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| 基金项目： | 国家863计划项目(10 2 10 0 2 0 3,2 19 0 1 0 3 0 1A),国家重点基础研究发展项目 (G19980 5 10 ) |
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| 摘 要： | 基因在决定个体表型方面起着决定性的作用。虽然单基因疾病的致病基因的克隆工作取得了显著的进展,但对于多基因疾病来说,仍然存在许多问题,同时也是巨大的挑战。本文综述了多基因疾病的遗传特点和多基因疾病易感基因识别、分离和克隆的一般步骤和存在的问题,介绍了人类基因组计划在此过程中的作用和单核苷酸多态性的应用前景,提出 了最有可能克隆出多基因疾病易感基因的策略和方法。
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| 关 键 词： | 多基因疾病 基因 单核苷酸多态性 |
Strategies and methods to identify genes for complex diseases |
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| Zhang K X,Zhu D L,Huang W. Strategies and methods to identify genes for complex diseases[J]. Progress in Physiological Sciences, 2001, 32(3): 215-219 |
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| Authors: | Zhang K X Zhu D L Huang W |
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| Affiliation: | Shanghai Institute of Hypertension, Chinese Human Genome Center at Shanghai, Shanghai 201203. |
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| Abstract: | Genes underlie numerous human diseases and traits. Although we have witnessed a great deal of success in identifying disease-susceptible genes, the task remains challenging for most of the complex diseases. This paper reviews evidence for the role of genetic factors in complex diseases, and strategies that can potentially optimize our chance of success in identifying genes involved in complex diseases. Advances in molecular biology, particularly mapping of the human genome, statistical methods that provide more accurate models of complex patterns of inheritance, and advances in basic medical science, which have increased our understanding of disease pathophysiology, will ultimately strengthen the ability of the current generation of genetic epidemiological studies to identify the genetic basis of complex human disorders. |
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| Keywords: | Complex diseases Gene Single nucleotide polymorphism |
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