| 超声心动图评定雄性Balb/c小鼠心脏形态和功能 |
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| 作者姓名： | Ma JZ Tang XX Zhu SS Wu HF Chen XJ Xu D Yang D Zhang JN |
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| 作者单位： | 南京医科大学第一附属医院心血管病研究所,江苏,南京,210029;解放军理工大学理学院军事系,江苏,211101 |
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| 基金项目： | 国家自然科学基金资助项目（30570745）：江苏省135重点实验室资助项目（SK200205） |
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| 摘 要： | 目的：应用超声心动图评定雄性Balb／c小鼠的心脏形态和功能。方法：应用13MHz线控阵超声探头检测27只Balb／c雄性小鼠心脏（周龄：5—7周）,超声检测后,进行戊巴比妥麻醉处死分离左室,测量湿重.结果：获得小鼠完整2维超声心动图,并记录雄性小鼠血流动力学参数：用M型超声心动图计算左室重量与左室湿重呈线性相关：y=1．15x＋3．26（r=0．80）。结论：超声心动图参数能够评定小鼠的心脏形态和功能。
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| 关 键 词： | 超声心动图 小鼠 左室重量 |
| 文章编号： | 1000-6834（2007）04-0390-04 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2007-07-23 |
Assessment of cardiac structure and function by echocardiographic values for male Balb/c mice |
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| Ma JZ,Tang XX,Zhu SS,Wu HF,Chen XJ,Xu D,Yang D,Zhang JN.Assessment of cardiac structure and function by echocardiographic values for male Balb/c mice[J].Chinese Journal of Applied Physiology,2007,23(4):390-393. |
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| Authors: | Ma Ji-zheng Tang Xiao-xia Zhu Shu-shu Wu Heng-fang Chen Xiang-jian Xu Di Yang Di Zhang Ji-nan |
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| Institution: | Institute of Cardiovascular Disease, the First Affliated Hospital of Naning Medical University, Naning 210029, China. |
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| Abstract: | Aim:To assess the parameters of cardiac structure and function of male Balb/c mice by the echocardiography.Methods:A total of 27 male Balb/c mice(from five to seven week old) were examined with a 13-MHz transthoracic linear-array transducer,hearts were removed from mice anesthetized with Butaylone,and the left ventricular(LV) mass were weighed.Results:Complete 2-dimensional echocardiography for cardiac structure and function were obtained.Hemodynamic parameters were recorded.A correlation existed between LV weight(x) and echocardiographic LV mass(y) with the 2D guided M-mode method:y=1.15x 3.26,(r=0.80).Conclusion:Echocardiography appears to be a promising approach for noninvasively assessing LV mass and function in mice. |
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| Keywords: | echocardiography mice left ventricular mass |
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