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Detection of an mRNA polymorphism by differential display |
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| Authors: | Shan Liang S. Paul Rossby Dr. Peng Liang Richard C. Shelton D. Hal Manier Amitabha Chakrabarti Fridolin Sulser |
| Affiliation: | (1) Department of Cell Biology, Vanderbilt University Medical Center, 649 MRB II, 37232-6838 Nashville, TN;(2) Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN;(3) Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN;(4) Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN |
| Abstract: | Differential Display (DD) technology was utilized to compare programs of gene expression in primary cultures of human skin fibroblasts from normal volunteers and patients diagnosed with melancholic depression. Polymorphic transcripts of a single gene differing by one tandem repeat sequence of four nucleotides (TGAT) in the 3' noncoding region were detected. |
| Keywords: | Differential Display PCR mRNA polymorphism variable number tandem repeats (VNTRs) |
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