Urinary mutagenicity tests in lead-exposed workers |
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Authors: | P Apostoli R Leone S Porru M E Fracasso L Alessio |
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Institution: | Cattedra di Medicina del Lavoro, University of Brescia, Italy. |
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Abstract: | Urinary mutagenic activity detected by the bacterial fluctuation assay, using Salmonella typhimurium TA98 and Escherichia coli WP2 uvrA with and without metabolic activation (S9 mix), was studied in a group of 21 workers exposed to inorganic lead and a control group of 22 non-occupationally exposed subjects. Occupational exposure to inorganic lead had no effect on urinary mutagenicity in the strains considered, with or without metabolic activation. In smokers (exposed and non-exposed), urinary mutagenic activity appeared to increase compared to non-smokers (exposed and non-exposed), only with Salmonella typhimurium TA98 in the presence of S9 mix. |
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