Mechanism of Kasugamycin Resistance in <Emphasis Type="Italic">Escherichia coli</Emphasis> |
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| Authors: | TERRY L HELSER JULIAN E DAVIES JAMES E DAHLBERG |
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| Institution: | 1.Department of Biochemistry, College of Agriculture and Life Sciences,University of Wisconsin,Madison;2.Department of Physiological Chemistry,University of Wisconsin,Madison |
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| Abstract: | Strains of Escherichia coli are resistant to the antibiotic kasugamycin due to the partial non-methylation of 16S ribosomal RNA. An RNA methylase activity, absent from resistant strains, is shown here to methylate in vitro the 16S RNA of resistant as well as sensitive strains. |
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