Growth Factors in Proliferative Diabetic Retinopathy |
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| Authors: | Zia Ali Khan Subrata Chakrabarti |
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| Affiliation: | 1. Department of Pathology, University of Western Ontario, Dental Sciences Building, London, Ontario, N6A 5C1, Canada.;2. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, |
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| Abstract: | Many growth factors are implicated in the pathogenesisof proliferative diabetic retinopathy. Alteration of growthfactors and their receptors in diabetes has been shown inboth experimental and clinical studies. Sustained hyperglycemiaresulting from long-standing diabetes leads to severalbiochemical abnormalities that consequently result inretinal hypoxia. Retinal oxygenation state regulates variousgrowth factors that promote angiogenesis in order to meetthe oxygen demands of the tissue. However, unregulated expressionof these growth factors and induction of complexcascades leading to augmentation of other proangiogenicfactors, which may not be regulated by tissue oxygenation,leads to uncontrolled retinal neovascularization and blindnessin diabetic patients. |
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