Sites of synthesis of plasma proteins in the foetal rat |
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Authors: | R W Wise and I T Oliver |
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Institution: | Department of Biochemistry, University of Western Australia, Nedlands, Western Australia |
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Abstract: | 1. The foetal rat of 16 or more days incorporates 14C-labelled amino acids into all the demonstrable plasma protein fractions in vivo. 2. Slices of foetal rat liver incubated in vitro incorporate 14C-labelled amino acids into the main plasma protein fractions, including the foetal-specific `post-albumin'. 3. Slices of placenta are unable to incorporate 14C-labelled amino acids into plasma proteins in vitro. 4. Liver slices from maternal rats incubated in vitro incorporate 14C-labelled amino acids into plasma proteins. The presence of post-albumin cannot be demonstrated after incubation. 5. Liver slices from foetal rats, but not from adult rats, contain demonstrable amounts of haemoglobin into which 14C-labelled amino acids are incorporated. |
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