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Class-specific antibody in human dermatophytosis reactive withTrichophyton rubrum derived antigen |
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| Authors: | Tareq Hamouda Charles D Jeffries Esmat M Ekladios Abla M El-Mishad Medhat El-Koomy Nadia Saleh |
| Institution: | (1) Department of Microbiology, Faculty of Medicine, Cairo University, Cairo, Egypt;(2) Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;(3) Department of Immunology and Microbiology, School of Medicine, Wayne State University, 540 East Canfield, 48201-1998 Detroit, MI, USA |
| Abstract: | Dermatophyte infections induce a humoral immune response and an enzyme linked immunosorbent assay was used to detect specific antibody classes against antigen derived fromTrichophyton rubrum. Sera from 19 acute patients, 18 chronic patients, and 27 normal controls were evaluated. Mean IgG titers against dermatophyte antigen were significantly higher in all patients than in controls. Mean IgM levels were significantly higher in acute patients than in controls. No significant difference was detected in IgE titers between the patients and controls. These results do not reveal whether the humoral immune response has a role in the progression of the infection.Abbreviations CMI cell-mediated immunity - PBS phosphate buffered saline - Tr antigen Trichophyton rubrum antigen |
| Keywords: | Antibody Dermatophytosis ELISA Trichophytin Trichophyton rubrum |
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