1,25-Dihydroxyvitamin D3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells |
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| Authors: | K Yamaoka S L Marion A Gallegos M R Haussler |
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| Affiliation: | 1. Division of Materials, Mechanics and Structures, Faculty of Engineering, University of Nottingham, UK;2. Division of Materials, Mechanics and Structures and University Technology Centre in Gas Turbine Transmission Systems, Faculty of Engineering, The University of Nottingham, Nottingham NG7 2RD, UK;1. Applied Physiology and Nutrition Research Group, Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil;2. Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK;3. Department of Biological Sciences, California State University, East Bay, Hayward, CA 94542, USA |
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| Abstract: | We tested the influence of daily subcutaneous injections of 12.5 and 25 pmol of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the growth of tumors arising from intracutaneous inoculations of athymic nude mice with rat osteogenic sarcoma cells (ROS) and human melanoma cells. Both doses of 1,25(OH)2D3 increased plasma calcium levels after 3 weeks and produced a striking enhancement in tumor weight when the mice received 1,25(OH)2D3 receptor-rich ROS17/2.8 cells. In contrast, 1,25(OH)2D3 caused no consistent effect on tumor weight in mice given G-361 melanoma cells with low receptor copy number or receptor deficient ROS 24/1 cells. Thus, 1,25(OH)2D3 stimulated tumor growth in a receptor dependent fashion, in vivo, instead of inhibiting it as predicted from the reduction of proliferation of cultured cells in the presence of 1,25(OH)2D3. |
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