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Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris. |
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| Authors: | M. Deepak G. Dipankar D. Prashanth M.K. Asha A. Amit B.V. Venkataraman |
| Affiliation: | aPhytochemistry Laboratory, R&D Centre, Natural Remedies Pvt. Ltd., Veerasandra Indl. Area, Bangalore, India bBioassay Unit, R&D Centre, Natural Remedies Pvt. Ltd., Veerasandra Indl. Area, Bangalore, India cDepartment of Pharmacology, St. Johns' Medical College, Bangalore, India |
| Abstract: | Successive extracts of Tribulus terrestris prepared using petroleum ether, chloroform, 50% methanol and water were tested for anthelmintic activity in-vitro using the nematode Caenorhabditis elegans. The activity could be detected only in 50% methanol extract which on further bioactivity guided fractionation and chromatographic separation yielded a spirostanol type saponin, tribulosin and beta-sitosterol-D-glucoside. Both the compounds exhibited anthelmintic activity with ED50 of 76.25 and 82.50 microg/ml respectively. |
| Keywords: | Tribulus terrestris tribulosin β-sitosterol-D-glucoside anthelmintic acitivty Caenorhabditis elegans |
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