Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6 |
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Authors: | Kamemura Kazuo Ogawa Mitsutaka Ohkubo Saki Ohtsuka Yasuhiro Shitara Yu Komiya Tohru Maeda Satoko Ito Akihiro Yoshida Minoru |
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Institution: | Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan. k_kamemura@nagahama-i-bio.ac.jp |
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Abstract: | Mitochondria perform multiple functions critical to the maintenance of cellular homeostasis. Here we report that the downregulation of histone deacetylase 6 (HDAC6) causes a reduction in the net activity of mitochondrial enzymes, including respiratory complex II and citrate synthase. HDAC6 deacetylase and ubiquitin-binding activities were both required for recovery of reduced mitochondrial metabolic activity due to the loss of HDAC6. Hsp90, a substrate of HDAC6, localizes to mitochondria and partly mediates the regulation of mitochondrial metabolic activity by HDAC6. Our finding suggests that HDAC6 regulates mitochondrial metabolism and might serve as a cellular homeostasis surveillance factor. |
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