High-throughput screening for Streptomyces antibiotic biosynthesis activators |
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| Authors: | Chen Li Wang Yemin Guo Hang Xu Min Deng Zixin Tao Meifeng |
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| Affiliation: | State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China. |
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| Abstract: | ![]()
A genomic cosmid library of Streptomyces clavuligerus was constructed and transferred efficiently by conjugation to Streptomyces lividans, and 12 distinct groups of overlapping cosmid clones that activated the silent actinorhodin biosynthesis gene cluster were identified. This generally applicable high-throughput screening procedure greatly facilitates the identification of antibiotic biosynthesis activators. |
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