Indole alkaloids from the leaves of Philippine Alstonia scholaris |
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| Authors: | Macabeo Allan Patrick G Krohn Karsten Gehle Dietmar Read Roger W Brophy Joseph J Cordell Geoffrey A Franzblau Scott G Aguinaldo Alicia M |
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| Institution: | Phytochemistry Laboratory, Research Center for the Natural Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana St., Manila 1008, Philippines. |
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| Abstract: | The first seco-uleine alkaloids, manilamine (1) (18-hydroxy-19,20-dehydro-7,21-seco-uleine) and N4-methyl angustilobine B (2), were isolated from the (pH 5) alkaloid extract of Philippine Alstonia scholaris leaves together with the known indole alkaloids 19,20-(E)-vallesamine (3), angustilobine B N4-oxide (4), 20(S)-tubotaiwine (5), and 6,7-seco-angustilobine B (6). The structure of the alkaloids was established from MS and NMR experiments. |
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| Keywords: | Alstonia scholaris Apocynaceae Manilamine N4-Methyl angustilobine B Mass spectrometry NMR spectroscopy Monoterpene indole alkaloid biogenesis |
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