Amino acids runs and genomic compositional biases in vertebrates |
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Authors: | Veitia Reiner A |
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Institution: | Université Denis Diderot/Paris VII, INSERM E0021 and U361, Reproduction et Physiopathologie Obstétricale, H?pital Cochin, Pavillon Baudelocque, 123 Boulevarde de Port Royal, 75014 Paris, France. veitia@cochin.inserm.fr |
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Abstract: | A compositional analysis of a sample of 50 zebrafish proteins containing at least one alanine run and of their open reading frames (ORFs) has been performed. The sample of poly(Ala) proteins showed a tendency to have runs of other amino acids (His/H, Gln/Q, Ser/S, Pro/P). Their ORFs and the first and second codon positions had higher GC contents than a reference gene set. The "universal" correlation between the GC content of the first+second and third codon positions (GC1+2 vs GC3) does not hold, but I provide an explanation in terms of genomic heterogeneity. Significant correlation between AHQS content and GC3 was obtained, reflecting codon bias favoring G/C at the third codon position of these amino acids. A correspondence analysis (COA) of relative synonymous codon usage showed that the poly(Ala) proteins have a biased distribution according to the second axis of the COA, which correlates with gene expression in zebrafish. A comparison with human is undertaken. |
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