| 表观遗传新标志物5hmC的研究进展 |
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| 引用本文： | 葛苗苗,蔡春.表观遗传新标志物5hmC的研究进展[J].生物化学与生物物理进展,2014,41(9):839-850. |
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| 作者姓名： | 葛苗苗 蔡春 |
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| 作者单位： | 广东医学院湛江科研中心,湛江 524023,广东医学院湛江科研中心,湛江 524023 |
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| 基金项目： | 国家自然科学基金资助项目(21375029)和广东医学院研究团队基金资助项目(TD1125) |
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| 摘 要： | 5-羟甲基胞嘧啶(5-hydroxymethylcytosine,5hmC)作为表观遗传的新标志物,已引起人们的极大兴趣.5hmC由TET家族酶催化氧化5-甲基胞嘧啶(5-methylcytosine,5mC)产生,被称为高等生物基因组DNA的"第六碱基".5hmC不仅可以影响基因组结构及功能,还在早期胚胎发育中发挥重要的作用.本文综述了5hmC的代谢通路、生物学功能、在基因组的分布及分析方法的研究进展.
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| 关 键 词： | -羟甲基胞嘧啶 TET蛋白 早期胚胎发育 |
| 收稿时间： | 9/6/2013 12:00:00 AM |
| 修稿时间： | 2014/1/30 0:00:00 |
Research Advances on The New Epigenetic Marker: 5-Hydroxymethylcytosine |
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| GE Miao-Miao and CAI Chun.Research Advances on The New Epigenetic Marker: 5-Hydroxymethylcytosine[J].Progress In Biochemistry and Biophysics,2014,41(9):839-850. |
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| Authors: | GE Miao-Miao and CAI Chun |
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| Institution: | Guangdong Medical College, Zhanjiang 524023, China and Guangdong Medical College, Zhanjiang 524023, China |
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| Abstract: | Recently, the new epigenetic marker, 5-hydroxymethylcytosine (5hmC) has been widely studied. 5hmC derived from the enzymatic oxidation of 5-methylcytosine (5mC) by TET(ten-eleven translocation) protein family and called as the "six base" of higher organism genomic DNA. It is found that 5hmC not only influence the structure and function of genome, but also play an important role during early embryonic development. This review mainly discussed the research advances of 5hmC in metabolic pathways, biological function, genome distribution and analysis methods. |
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| Keywords: | 5-hydroxymethylcytosine TET proteins early embryonic development |
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