Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein |
| |
| Authors: | Yin Hang Hamilton Andrew D |
| |
| Affiliation: | Department of Chemistry, Yale University, PO Box 20810, New Haven, CT 06511, USA. |
| |
| Abstract: | ![]()
A group of novel Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, were designed to mimic the alpha-helical region of the Bak peptide. Good in vitro inhibition potencies in disrupting the Bak/Bcl-xL complex have been observed (terephthalamide 4, K(i)=0.78+/-0.07 microM). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
