Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

Authors:	Florian Maria Carolina Dörr Karin Niebel Anja Daria Deidre Schrezenmeier Hubert Rojewski Markus Filippi Marie-Dominique Hasenberg Anja Gunzer Matthias Scharffetter-Kochanek Karin Zheng Yi Geiger Hartmut

Affiliation:	1. Department of Dermatology and Allergic Diseases, University of Ulm, 89091 Ulm, Germany;2. Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, University of Ulm, 89091 Ulm, Germany;3. Division of Experimental Hematology and Cancer Biology, Cincinnati Children''s Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229-3026, USA;4. Institute of Experimental Immunology and Imaging, University Hospital, Universität Duisburg/Essen, 45141 Essen, Germany

Abstract:	Download : Download high-res image (312KB) Download : Download full-size image Highlights? Constitutively increasing Cdc42 activity causes aging of young HSCs ? Elevated Cdc42 activity correlates with a loss of cell polarity in aged HSCs ? Inhibition of Cdc42 activity rejuvenates aged LT-HSC function ? Cdc42 inhibition restores the level and spatial distribution of AcH4K16

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