Chemical synthesis of oligonucleotides containing (M+4) guanine |
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Authors: | Guo Ruoling Zheng Qinguo |
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Institution: | School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. guor@aston.ac.uk |
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Abstract: | HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. |
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