A highly efficient deprotection of the 2,2,2-trichloroethyl group at the anomeric oxygen of carbohydrates |
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| Authors: | Zhang Jianbo Fu Jie Si Wenshuai Wang Xiaohu Wang Zhongfu Tang Jie |
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| Affiliation: | aDepartment of Chemistry, East China Normal University, Shanghai 200062, China;bSchool of Life Sciences, Northwest University, Xi’an 710069, China |
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| Abstract: | Commercially available zinc dust in the presence of ammonium chloride in acetonitrile at reflux removes the 2,2,2-trichloroethyl (TCE) group at anomeric centers with excellent yields (>95%) in short reaction times. This present method is easily implemented on substrates containing acyl and benzyl groups and large-scale reactions also proceed in high yield. |
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| Keywords: | 2,2,2-Trichloroethyl Anomeric center Carbohydrates Deprotection Zinc dust |
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